| Primary Identifier | MGI:99435 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 11845 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including G protein activity; guanyl ribonucleotide binding activity; and thioesterase binding activity. Involved in several processes, including positive regulation of focal adhesion disassembly; positive regulation of keratinocyte migration; and regulation of protein localization. Acts upstream of or within several processes, including erythrocyte apoptotic process; hepatocyte apoptotic process; and liver development. Located in endosome and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and respiratory system. Orthologous to human ARF6 (ARF GTPase 6). PHENOTYPE: Mice homozygous for a null allele display embryonic and perinatal lethality beginning around mid-gestation, impaired liver development, and edema. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
