| Primary Identifier | MGI:105108 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 18080 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables microtubule minus-end binding activity. Acts upstream of or within several processes, including axonogenesis; microtubule cytoskeleton organization; and positive regulation of axonogenesis. Located in several cellular components, including axonal growth cone; dendrite; and microtubule cytoskeleton. Part of ciliary transition fiber. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in Seckel syndrome 7. Orthologous to human NIN (ninein). PHENOTYPE: Mice homozygous for a knock-out allele exhibit partial pre- and postnatal lethality, thinner skin, delayed skin barrier formation, impaired skin barrier function, impaired differentiation of suprabasal cells, and defects in mitotic spindle orientation, desmosome assembly and lamellar body secretion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
