| Primary Identifier | MGI:97600 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 18755 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables small GTPase binding activity. Involved in positive regulation of keratinocyte differentiation and positive regulation of macrophage derived foam cell differentiation. Located in cell-cell junction; cytosol; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human PRKCH (protein kinase C eta). PHENOTYPE: Mice homozygous for a knock-out allele exhibit thymus hypoplasia, enlarged lymph nodes and alterations in T cell homeostasis and activation. Mice homozygous for a different knock-out allele show impaired wound healing and increased incidence of tumors by chemical induction. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
