Primary Identifier | MGI:1931551 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 80837 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in actin cytoskeleton organization. Acts upstream of or within Rho protein signal transduction; regulation of cell shape; and retina vasculature morphogenesis in camera-type eye. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; retina; and vertebral axis musculature. Orthologous to human RHOJ (ras homolog family member J). PHENOTYPE: Mice homozygous for a knock-out allele exhibit a slight delay in radial growth in the retina and empty basement membrane sleeves. [provided by MGI curators] |