| Primary Identifier | MGI:2135760 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 81535 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables sphingosine-1-phosphate phosphatase activity. Involved in regulation of keratinocyte differentiation. Acts upstream of or within apoptotic signaling pathway and sphingolipid metabolic process. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including adrenal gland; alimentary system; heart; liver; and urinary system. Orthologous to human SGPP1 (sphingosine-1-phosphate phosphatase 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal keratinocyte differentiation and epidermal homeostasis with postnatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
