| Primary Identifier | MGI:1861305 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 110606 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables farnesyltranstransferase activity. Acts upstream of or within negative regulation of cell population proliferation; positive regulation of fibroblast proliferation; and wound healing. Predicted to be part of microtubule associated complex and protein farnesyltransferase complex. Human ortholog(s) of this gene implicated in anxiety disorder. Orthologous to several human genes including FNTB (farnesyltransferase, CAAX box, subunit beta). PHENOTYPE: Mice homozygous for a knock-out allele exhibit early embryonic lethality and loss epiblast-derived structures as a result of decreased cell proliferation and increased apoptosis. Cultured blastocysts corresponding to E7.5 embryos display a dramatic decrease in inner cell mass proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
