| Primary Identifier | MGI:106609 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 14776 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables glutathione peroxidase activity. Acts upstream of or within several processes, including negative regulation of inflammatory response to antigenic stimulus; response to symbiotic bacterium; and temperature homeostasis. Predicted to be located in cytosol; intercellular bridge; and mitotic spindle. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human GPX2 (glutathione peroxidase 2). PHENOTYPE: Homozygotes for a targeted null allele appear normal, but double knockouts of Gpx1 and Gpx2 exhibit symptoms of inflammatory bowel disease, including perianal ulceration, growth retardation, and hypothermia, a condition that is sometimes fatal not observed in either single knockout. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
