| Primary Identifier | MGI:1922485 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 97827 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable 3'-5' exonuclease activity; metal ion binding activity; and protein homodimerization activity. Predicted to be involved in DNA double-strand break processing; double-strand break repair via homologous recombination; and replication fork processing. Predicted to be located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; ganglia; and neural retina. Orthologous to human EXD2 (exonuclease 3'-5' domain containing 2). PHENOTYPE: Mice homozygous for a mutation in the exonuclease domain of the gene are viable, overtly normal, and exhibit normal male fertility, despite misregulation of PIWI-interacting RNAs (piRNA) levels originating from specific pachytene piRNA clusters. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
