| Primary Identifier | MGI:97379 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 20493 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable bile acid:sodium symporter activity. Predicted to be involved in bile acid and bile salt transport. Located in membrane. Is expressed in 1-cell stage embryo; 2-cell stage embryo; and liver. Orthologous to human SLC10A1 (solute carrier family 10 member 1). PHENOTYPE: Mice homozygous for a knock-out allele show impaired hepatic uptake of conjugated bile acids (BAs) and Myrcludex B binding. A subset of adult homozygotes exhibit hypercholanemia, reduced body weight, increased serum alkaline phosphatase and bilirubin levels but no overt liver damage. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
