Primary Identifier | MGI:1926195 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 56531 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of telomere maintenance. Located in nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and immune system. Orthologous to human YLPM1 (YLP motif containing 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete lethality prior to organogenesis. [provided by MGI curators] |