Primary Identifier | MGI:1916394 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 380773 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable mRNA 3'-UTR binding activity and poly(G) binding activity. Acts upstream of or within several processes, including flagellated sperm motility; negative regulation of mitochondrial RNA catabolic process; and spermatid development. Located in several cellular components, including acrosomal vesicle; perinuclear region of cytoplasm; and sperm flagellum. Part of ribonucleoprotein complex. Is expressed in ovary and seminiferous cord. Orthologous to human SLIRP (SRA stem-loop interacting RNA binding protein). PHENOTYPE: Homozygous inactivation of this gene results in partial preweaning lethality and reduced male fertility characterized by asthenozoospermia and abnormal sperm annulus and sperm mitochondrial sheath morphology. [provided by MGI curators] |