| Primary Identifier | MGI:1933277 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 83602 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in positive regulation of transcription initiation by RNA polymerase II and transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription factor TFIIA complex. Is expressed in several structures, including early conceptus; genitourinary system; liver; olfactory epithelium; and spleen. Orthologous to human GTF2A1 (general transcription factor IIA subunit 1). PHENOTYPE: Mice homozygous for a hypomorphic allele where D/G cleavage residues are replaced with noncleavable A/A show neonatal lethality, feeding defects, low testis weight, and male infertility associated with azoospermia, small seminiferous tubules, lack of elongating spermatids, and increased apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
