| Primary Identifier | MGI:2441763 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 238377 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable G protein-coupled receptor activity. Acts upstream of or within cellular response to pH; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of myeloid leukocyte differentiation. Predicted to be located in plasma membrane. Is expressed in cerebral cortex; early conceptus; primary oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A6. Orthologous to human GPR68 (G protein-coupled receptor 68). PHENOTYPE: Mice homozygous for a null allele exhibit decreased osteoclastogenesis, abnormal pH-sensitive osteoclast survival, and background sensitive alterations in brown adipose tissue, monocytes, and macrophages. Mice homozygous for a different allele exhibit attenuated glucose-stimulated insulin secretion. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
