Primary Identifier | MGI:1915984 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 68734 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein phosphatase activator activity. Acts upstream of or within positive regulation of gluconeogenesis and protein dephosphorylation. Located in cytoplasm and nucleus. Part of protein phosphatase 4 complex. Is expressed in several structures, including central nervous system; heart; and retina nuclear layer. Orthologous to human PPP4R3A (protein phosphatase 4 regulatory subunit 3A). PHENOTYPE: Mice homozygous for a conditional allele exhibit increased anxiety- and depression-related behaviors with decreased miniature excitatory postsynaptic currents, decreased glutamate release, and decreased dendritic spine density. [provided by MGI curators] |