| Primary Identifier | MGI:2385708 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 217835 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in signal transduction and vesicle-mediated transport. Predicted to act upstream of or within negative regulation of receptor internalization and regulation of vesicle size. Located in axon; dendrite; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human RIN3 (Ras and Rab interactor 3). PHENOTYPE: Mice homozygous for a knock-out allele show an age-dependent increase in trabecular bone volume and trabecular number, a decrease in trabecular separation and osteoclast surface, and increased perimeter occupied by single calcein labels, thus reducing bone resorption and leading to increased bone mass. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
