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Protein Coding Gene : Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K
Primary Identifier  MGI:98377 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  20714
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to cytokine and response to peptide hormone. Located in collagen-containing extracellular matrix. Is expressed in axial skeleton; liver; nervous system; and thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3).
PHENOTYPE: Mice homozygous for a knock-out allele are viable and show decreased susceptibility to kidney reperfusion injury [provided by MGI curators]
  • synonyms:
  • Serpina3k,
  • D12Rp54,
  • RIKEN cDNA 1300001I07 gene,
  • Roswell Park 54,
  • Spi2,
  • alpha-1 antiproteinase,
  • 1300001I07Rik,
  • MGD-MRK-3357,
  • contrapsin,
  • MGD-MRK-14521,
  • Spi-2,
  • serine protease inhibitor 2,
  • serine protease inhibitor-2 (prob. = Pre-1 or -2) [contrapsin],
  • MGD-MRK-14022,
  • RP54,
  • DNA segment, Chr 12, Roswell Park 54,
  • MMSpi2,
  • MGI:1915688,
  • serine (or cysteine) peptidase inhibitor, clade A, member 3K,
  • MMCM2,
  • MGD-MRK-14526
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