| Primary Identifier | MGI:2177178 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 192119 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables miRNA binding activity. Involved in several processes, including nervous system development; regulation of macromolecule metabolic process; and regulation of nervous system development. Acts upstream of or within several processes, including circulatory system development; negative regulation of macromolecule metabolic process; and nervous system development. Located in cytoplasm. Part of RISC complex and RISC-loading complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study DiGeorge syndrome; dilated cardiomyopathy; and ovarian cancer. Human ortholog(s) of this gene implicated in DICER1 syndrome; gastrointestinal system cancer (multiple); multinodular goiter; nephroma; and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III). PHENOTYPE: Mutation of this locus results in arrest of early embryonic development. Inducible muscle-specific KO results in impaired muscle regeneration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
