| Primary Identifier | MGI:1097166 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 21432 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activator activity. Involved in activation of protein kinase B activity. Acts upstream of or within negative regulation of gene expression; regulation of stem cell population maintenance; and somatic stem cell population maintenance. Located in cell cortex; ooplasm; and pronucleus. Is expressed in several structures, including early conceptus; hemolymphoid system gland; liver; and seminiferous cord. Orthologous to human TCL1A (TCL1 family AKT coactivator A). PHENOTYPE: Mice homozygous for a knock-out allele display a maternal fertility defect that leads to a progressive reduction in litter size and a shortened reproductive lifespan. Reduced female fertility is caused by impaired blastomere proliferation in the early preimplantation embryo. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
