| Primary Identifier | MGI:1289184 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 52690 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and protein methyltransferase activity. Involved in actin modification; peptidyl-histidine methylation; and regulation of uterine smooth muscle contraction. Acts upstream of or within positive regulation of muscle cell differentiation and positive regulation of transcription by RNA polymerase II. Located in chromatin. Orthologous to human SETD3 (SET domain containing 3, actin N3(tau)-histidine methyltransferase). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired migration of MEFs, reduced litter size from female mice and primary dystocia. Homozygous KO also protects against enterovirus infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
