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Protein Coding Gene : Begain brain-enriched guanylate kinase-associated
Primary Identifier  MGI:3044626 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  380785
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Involved in regulation of postsynaptic neurotransmitter receptor activity. Acts upstream of or within evoked excitatory postsynaptic potential. Located in presynapse. Is active in glutamatergic synapse. Is expressed in central nervous system; eye; and lip. Orthologous to human BEGAIN (brain enriched guanylate kinase associated).
PHENOTYPE: Mice homozygous for a null allele display abnormal evoked NMDAR excitatory postsynaptic currents, and abnormalities in long-term spatial reference memory, extinction of fear memory and pain thresholds after injury. [provided by MGI curators]
  • synonyms:
  • gene model 897, (NCBI),
  • LOC380785,
  • expressed sequence BM948371,
  • Begain,
  • brain-enriched guanylate kinase-associated,
  • MGI:2685743,
  • Gm897,
  • BM948371
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