| Primary Identifier | MGI:1341865 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 17169 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable tau-protein kinase activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; negative regulation of protein localization to nucleus; and peptidyl-serine autophosphorylation. Predicted to be located in dendrite. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; liver; and retina. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3). PHENOTYPE: Homozygous disruption of this gene results in decreased body weight, increased energy expenditure, reduced adiposity, and protection from high-fat diet induced obesity. On a high-fat diet, mice show resistance to hepatic steatosis, improved glucose tolerance, and decreased insulin levels. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
