| Primary Identifier | MGI:1921585 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 74335 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ATP binding activity and ATP-dependent DNA damage sensor activity. Predicted to contribute to crossover junction DNA endonuclease activity and four-way junction DNA binding activity. Predicted to be involved in DNA metabolic process and regulation of cell cycle process. Predicted to be located in several cellular components, including mitochondrion; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of Rad51C-XRCC3 complex. Predicted to be active in replication fork. Is expressed in several structures, including adipose tissue; adrenal gland; brain; gonad; and submandibular gland. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); central nervous system cancer (multiple); familial melanoma; multiple myeloma; and pancreatic cancer. Orthologous to human XRCC3 (X-ray repair cross complementing 3). PHENOTYPE: Mice homozygous for a null allele exhibit growth arrest at the 6-8 somite stage prior to axial rotation and embryonic lethality during organogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
