Primary Identifier | MGI:2150037 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 116870 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coactivator activity. Involved in several processes, including circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and locomotor rhythm. Located in cytoplasm and nucleus. Part of NuRD complex. Is expressed in several structures, including brain; early conceptus; eye; genitourinary system; and mandibular process mesenchyme. Orthologous to human MTA1 (metastasis associated 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased cellular sensitivity to ionizing radiation and increased retinal cell proliferation at E14.5. [provided by MGI curators] |