Primary Identifier | MGI:96444 | Organism | mouse, laboratory |
Chromosome | 12 | Mgi Type | gene segment |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables antigen binding activity. Acts upstream of or within humoral immune response mediated by circulating immunoglobulin and mucosal immune response. Part of immunoglobulin complex, circulating. Is expressed in large intestine and small intestine. Orthologous to human IGHA1 (immunoglobulin heavy constant alpha 1) and IGHA2 (immunoglobulin heavy constant alpha 2 (A2m marker)). PHENOTYPE: Homozygous null mice have no detectable levels of IgA, decreased levels of IgG3, and increased levels of most other classes of immunoglobulins. [provided by MGI curators] |