Primary Identifier | MGI:99845 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 14569 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Contributes to GTPase activator activity. Acts upstream of or within small GTPase-mediated signal transduction. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human GDI2 (GDP dissociation inhibitor 2). PHENOTYPE: Knock-out results in embryonic lethality between E10.5 to E14.5, with extensive cell death and cell loss is embryos and increased apoptosis in E12.5 livers. [provided by MGI curators] |