| Primary Identifier | MGI:1914725 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 67475 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein-disulfide reductase activity. Involved in insulin processing. Acts upstream of or within several processes, including cell redox homeostasis; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; and protein maturation by protein folding. Located in membrane. Is active in endoplasmic reticulum lumen. Is expressed in heart and hindlimb joint. Orthologous to human ERO1B (endoplasmic reticulum oxidoreductase 1 beta). PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased circulating glucose levels, decreased pancreas insulin levels, and disorganized islets. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
