| Primary Identifier | MGI:892010 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 20379 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable Wnt-protein binding activity. Involved in bone morphogenesis; negative regulation of Wnt signaling pathway; and regulation of BMP signaling pathway. Predicted to be located in cell surface and nucleus. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; brain; eye; lung; and urinary system. Human ortholog(s) of this gene implicated in metaphyseal dysplasia. Orthologous to human SFRP4 (secreted frizzled related protein 4). PHENOTYPE: Mice homozygous for one null allele exhibit reduced litter size produced from female mice while mice homozygous for another exhibit hyper-fertile female mice and increased litter size. Mice homozygous for a different null allele exhibit increased trabecular bone mass, decreased compact bone thickness, and protection from age-related osteoporosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
