Primary Identifier | MGI:104886 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 14780 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable glutathione peroxidase activity. Acts upstream of or within cellular response to oxidative stress. Located in extracellular space and sperm plasma membrane. Is expressed in several structures, including male reproductive gland or organ and placenta. Orthologous to human GPX5 (glutathione peroxidase 5). PHENOTYPE: Male mice homozygous for a knock-out allele exhibit age-dependent reduced fertility due to increased sensitivity of sperm DNA to oxidative attack. [provided by MGI curators] |