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Protein Coding Gene : H1f3 H1.3 linker histone, cluster member
Primary Identifier  MGI:107502 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  14957
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables DNA binding activity. A structural constituent of chromatin. Acts upstream of or within chromatin organization and negative regulation of transcription by RNA polymerase II. Predicted to be located in euchromatin. Predicted to be part of nucleosome. Predicted to be active in nucleus. Is expressed in brain; early conceptus; oocyte; and pancreas epithelium. Orthologous to human H1-3 (H1.3 linker histone, cluster member).
PHENOTYPE: Homozygotes for targeted null mutations are phenotypically normal. However, Hist1h1c/Hist1h1e/Hist1h1d triple knockout mice die by embryonic day 12.5, and heterozygotes are underrepresented. [provided by MGI curators]
  • synonyms:
  • MGI:6324984,
  • H1.3 linker histone, cluster member,
  • H1f3,
  • histone cluster 1, H1d,
  • H1s-4,
  • H1D,
  • MGD-MRK-36072,
  • Hist1h1d,
  • H1.3,
  • H1 histone family, member 3
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Features --> Cross References

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1 Genomic Clusters

2 Involved In Mutations

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