| Primary Identifier | MGI:1931526 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 50708 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA binding activity. A structural constituent of chromatin. Acts upstream of or within chromatin organization and negative regulation of transcription by RNA polymerase II. Located in euchromatin. Is expressed in cerebral cortex ventricular layer; early conceptus; embryo; midbrain ventricular layer; and telencephalon ventricular layer. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human H1-2 (H1.2 linker histone, cluster member). PHENOTYPE: Homozygotes for targeted null mutations are normal, but Hist1h1c/Hist1h1e double knockout males are significantly smaller than normal. The Hist1h1c/Hist1h1e/Hist1h1d triple knockout is lethal by embryonic day 12.5, and heterozygotes are underrepresented. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
