Primary Identifier | MGI:1914084 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 66834 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables fatty acyl-CoA hydrolase activity. Involved in negative regulation of cold-induced thermogenesis. Located in mitochondrial matrix. Is expressed in chondrocranium; hindgut; and midgut. Orthologous to human ACOT13 (acyl-CoA thioesterase 13). PHENOTYPE: Mice homozygous for a knock-out allele exhibit altered adaptive thermorgenesis, decreased body weight, reduced white adipose tissue and abnormal hepatic lipid and glucose metabolism, especially in mice fed a high fat diet. [provided by MGI curators] |