| Primary Identifier | MGI:1915926 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 105352 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein tyrosine kinase binding activity and protein tyrosine phosphatase activity. Acts upstream of or within several processes, including negative regulation of T cell mediated immunity; regulation of signal transduction; and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm and leading edge of lamellipodium. Predicted to be part of filamentous actin. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and somite. Orthologous to human DUSP22 (dual specificity phosphatase 22). PHENOTYPE: Mice homozygous for a null allele develop inflammation and autoimmunity as they age, are more susceptible to experimental autoimmune encephalomyelitis, exhibit enhanced T-cell mediated and reduced B-cell mediated immune responses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
