| Primary Identifier | MGI:1096873 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 16364 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity; cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Involved in defense response to protozoan; mononuclear cell differentiation; and positive regulation of metabolic process. Acts upstream of or within chromatin remodeling; negative regulation of toll-like receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Part of nucleosome. Is expressed in several structures, including eye; hemolymphoid system; liver; mandible; and testis. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and pigmentation disease. Orthologous to human IRF4 (interferon regulatory factor 4). PHENOTYPE: Mice homozygous for disruptions in this gene display immune system abnormalities involving development of both T and B cells and affecting susceptibility to both bacterial and viral infections as well as impaired thermogenic gene expression and energy expenditure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
