Primary Identifier | MGI:1913732 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 66482 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane transport; regulation of entry of bacterium into host cell; and vesicle docking involved in exocytosis. Predicted to act upstream of or within positive regulation of exocytosis. Predicted to be located in plasma membrane. Predicted to be part of exocyst. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and palatal shelf. Orthologous to human EXOC2 (exocyst complex component 2). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis, and failure of blastocysts to hatch from the zona pellucida with increased cell death during outgrowth culture. [provided by MGI curators] |