| Primary Identifier | MGI:1913472 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 66222 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including inflammatory response; negative regulation of interleukin-1 beta production; and type B pancreatic cell proliferation. Acts upstream of or within regulation of protein catabolic process. Located in extracellular region. Is expressed in bladder wall; brain; embryo mesenchyme; gut; and liver lobe. Orthologous to human SERPINB1 (serpin family B member 1). PHENOTYPE: Homozygous null mice fail to clear P. aeruginosa lung infection and show increased mortality associated with late-onset failed bacterial clearance, partly due to elevated neutrophil necrosis, release of neutrophil protease activity, higher cytokine production and proteolysis of surfactant protein-D. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
