| Primary Identifier | MGI:106603 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 20723 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including T cell mediated cytotoxicity; acute inflammatory response to antigenic stimulus; and negative regulation of T cell apoptotic process. Located in cytoplasm. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human SERPINB9 (serpin family B member 9). PHENOTYPE: Homozygous null mice show defective CTL immunity and clearance of LCMV. Following infection with LCMV or L. monocytogenes, mutant CTLs display a breakdown of cytotoxic granule integrity, increased cytoplasmic granzyme B, and reduced survival due to increased granzyme B-mediated apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
