| Primary Identifier | MGI:108212 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 19766 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein homodimerization activity; protein serine/threonine kinase activity; and signaling adaptor activity. Involved in several processes, including necroptotic signaling pathway; negative regulation of necroptotic process; and regulation of signal transduction. Acts upstream of or within regulation of extrinsic apoptotic signaling pathway; regulation of reactive oxygen species metabolic process; and ripoptosome assembly involved in necroptotic process. Predicted to be located in mitochondrion. Predicted to be part of death-inducing signaling complex; receptor complex; and ripoptosome. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; immune system; limb; liver; and lung. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). PHENOTYPE: Mice homozygous for disruptions in this gene die within 1 and 3 days of birth displaying extensive apoptosis in both lymphoid and adipose tissue. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
