Primary Identifier | MGI:2384986 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 218215 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of apoptotic process and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in mitochondrial membrane. Is expressed in several structures, including bladder; cranium; hindbrain ventricular layer; jaw; and thoracic segment skeleton. Orthologous to human RNF144B (ring finger protein 144B). PHENOTYPE: Homozygous null mice exhibit decreased susceptibility to encephalomyocarditis virus (EMCV) infection and higher survival rate and MEFs show impaired vesicular stomatitis virus replication. [provided by MGI curators] |