| Primary Identifier | MGI:1196617 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 18081 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cell-cell adhesion mediator activity; lipopolysaccharide binding activity; and membrane destabilizing activity. Involved in several processes, including ferroptosis; leukocyte chemotaxis; and positive regulation of defense response. Acts upstream of or within hyaloid vascular plexus regression and positive regulation of cell-matrix adhesion. Located in extracellular region; filopodium membrane; and synaptic membrane. Is active in plasma membrane. Is expressed in several structures, including body cavity or lining; central nervous system; eye; genitourinary system; and vertebral axis musculature. Orthologous to human NINJ1 (ninjurin 1). PHENOTYPE: Homozygotes for a null allele die prematurely exhibiting hydroencephaly and abnormal cellular replicative senescence. Homozygotes for another null allele show resistance to EAE due to reduced leukocyte recruitment into lesion sites, and may display stunted growth, hydroencephaly, and ataxia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
