Primary Identifier | MGI:1913447 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 66197 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity. Acts upstream of or within several processes, including fibroblast proliferation; mitotic cell cycle phase transition; and regulation of transcription by RNA polymerase II. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Is expressed in branchial arch; cerebellum; and telencephalon. Orthologous to human CKS2 (CDC28 protein kinase regulatory subunit 2). PHENOTYPE: Mice homozygous for a knock-out allele are viable but sterile in both sexes due to failure of both male and female germ cells to progress beyond the first meiotic metaphase. [provided by MGI curators] |