| Primary Identifier | MGI:109495 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 18030 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in natural killer cell differentiation; negative regulation of DNA-templated transcription; and positive regulation of DNA-templated transcription. Acts upstream of or within cellular response to interleukin-4 and positive regulation of gene expression. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and heart. Used to study inflammatory bowel disease. Orthologous to human NFIL3 (nuclear factor, interleukin 3 regulated). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased NK cell differentiation, numbers, and activity. Mice homozygous for a different knock-out allele exhibit reduced class switching and IgE production. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
