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Protein Coding Gene : Cplx2 complexin 2
Primary Identifier  MGI:104726 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  12890
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable calcium-dependent protein binding activity and syntaxin-1 binding activity. Involved in positive regulation of synaptic plasticity and regulation of synaptic vesicle fusion to presynaptic active zone membrane. Is active in calyx of Held and glutamatergic synapse. Is expressed in nervous system; retina layer; and skeletal muscle. Used to study schizophrenia. Orthologous to human CPLX2 (complexin 2).
PHENOTYPE: Mice homozygous for disruptions in this gene display a variety of neurological abnormalities related to coordination, learning, and social interaction. [provided by MGI curators]
  • synonyms:
  • MGI:5594002,
  • Gm34843,
  • expressed sequence AW492120,
  • 921-L,
  • MGI:2145432,
  • MGI:2145225,
  • AW492120,
  • AI413745,
  • expressed sequence AI413745,
  • complexin 2,
  • Cplx2,
  • MGD-MRK-27089,
  • predicted gene, 34843
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