Primary Identifier | MGI:1920916 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 73666 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in nuclear speck. Predicted to be part of THO complex part of transcription export complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human THOC3 (THO complex subunit 3). PHENOTYPE: Mice homozygous for a knock-out allele show failure of morula compaction and complete embryonic lethality prior to organogenesis. In vitro outgrowth assays show that embryos hatch from the zona pellucida but form atypical outgrowths with an abnormal inner cell mass and few trophectoderm cells. [provided by MGI curators] |