Primary Identifier | MGI:1923827 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 76577 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including enzyme binding activity; lipase inhibitor activity; and ubiquitin binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in lipid droplet. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human FAF2 (Fas associated factor family member 2). PHENOTYPE: Mice homozygous for a conditional allele activated in the liver exhibit high-fat diet-induced periportal steatosis with reduced circulating lipid levels and ApoB secretion. [provided by MGI curators] |