Primary Identifier | MGI:104987 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 17121 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of DNA-templated transcription. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; genitourinary system; limb mesenchyme; retina; and thymus. Orthologous to human MXD3 (MAX dimerization protein 3). PHENOTYPE: Mice homozygous for disruptions in this gene have an essentially normal phenotype. The show an increased sensitivity to gamma irradiation. [provided by MGI curators] |