| Primary Identifier | MGI:1859709 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 51791 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GTPase activating protein binding activity and GTPase activator activity. Involved in several processes, including learning or memory; negative regulation of signal transduction; and regulation of synaptic plasticity. Acts upstream of or within mitotic cell cycle. Located in several cellular components, including dendritic spine; microtubule cytoskeleton; and nuclear body. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including cochlea; neural ectoderm; and placenta. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14). PHENOTYPE: Homozygosity for one knockout allele results in failure to complete the first zygotic cell division. Another homozygous KO affects long-term potentiation in hippocampal neurons which leads to enhanced spatial learning and long-term memory. A third homozygous KO results in no obvious phenotype. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
