| Primary Identifier | MGI:1347078 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 26385 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable G protein-coupled receptor kinase activity and beta-adrenergic receptor kinase activity. Predicted to be involved in desensitization of G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; liver; lung; spleen; and submandibular gland primordium. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GRK6 (G protein-coupled receptor kinase 6). PHENOTYPE: Whereas, homozygous mutant mice are viable and show no gross anatomical or behavioral abnormalites under normal physiological conditions, they exhibit locomotor supersensitivity to psychostimulants including cocaine and amphetamine. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
