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Protein Coding Gene : Ddx41 DEAD box helicase 41
Primary Identifier  MGI:1920185 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  72935
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables DNA binding activity. Acts upstream of or within cellular response to interferon-beta; defense response to virus; and positive regulation of transcription by RNA polymerase II. Located in endoplasmic reticulum and nucleus. Is expressed in hippocampus; pancreas; and testis. Human ortholog(s) of this gene implicated in myeloproliferative neoplasm. Orthologous to human DDX41 (DEAD-box helicase 41).
PHENOTYPE: Constitutive homozygous knockout is embryonic lethal. Conditional homozygous KO in macrophages and DCs (dendritic cells) leads to a depressed immune response to viral infection. [provided by MGI curators]
  • synonyms:
  • expressed sequence AI324246,
  • Ddx41,
  • 2900024F02Rik,
  • RIKEN cDNA 2900024F02 gene,
  • AA958953,
  • AI324246,
  • DEAD box helicase 41,
  • MGI:2145211,
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 41,
  • expressed sequence AA958953,
  • MGI:2145174
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

9 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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