Primary Identifier | MGI:1920895 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 212880 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent activity, acting on DNA. Predicted to be involved in U2-type prespliceosome assembly. Predicted to be located in fibrillar center and nuclear speck. Predicted to be part of U2-type spliceosomal complex. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer. Orthologous to human DDX46 (DEAD-box helicase 46). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality by E7.5. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture. [provided by MGI curators] |