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Protein Coding Gene : Ddx46 DEAD box helicase 46

Primary Identifier  MGI:1920895 Organism  mouse, laboratory
Chromosome  13 NCBI Gene Number  212880
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATP-dependent activity, acting on DNA. Predicted to be involved in U2-type prespliceosome assembly. Predicted to be located in fibrillar center and nuclear speck. Predicted to be part of U2-type spliceosomal complex. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer. Orthologous to human DDX46 (DEAD-box helicase 46).
PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality by E7.5. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture. [provided by MGI curators]
  • synonyms:
  • MGI:1918802,
  • AI957095,
  • DEAD box helicase 46,
  • MGI:2145213,
  • 2200005K02Rik,
  • Ddx46,
  • RIKEN cDNA 8430438J23 gene,
  • expressed sequence AI325430,
  • MGI:2145315,
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 46,
  • 8430438J23Rik,
  • expressed sequence AI957095,
  • AI325430,
  • RIKEN cDNA 2200005K02 gene

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1 Involved In Mutations

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Canonical gene --> CDSs in specific strains.

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