| Primary Identifier | MGI:2385852 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 212937 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables deubiquitinase activator activity. Acts upstream of with a negative effect on toll-like receptor signaling pathway. Acts upstream of or within several processes, including hemopoiesis; lipopolysaccharide-mediated signaling pathway; and regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. Orthologous to human TIFAB (TIFA inhibitor). PHENOTYPE: Mice homozygous for a knock-out allele exhibit progressive hematopoietic defects, including skewed hematopoietic stem/progenitor cell proportions, altered myeloid differentiation, a bone marrow failure-like disease associated with bone marrow dysplasia and cytopenia, and premature death. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
